Kapadia BH, Berg RA, Daley JA, Fritz J, Bhave A, Mont MA. Periprosthetic joint infection. Lancet. 2016;387(10016):386-394. doi: 10.1016/s0140-6736(14)61798-0   Willyard C. The drug-resistant bacteria that pose the greatest health threats. Nature. 2017;543(7643):15. doi: 10.1038/nature.2017.21550   Rumbaugh KP, Sauer K. Biofilm dispersion. Nat Rev Microbiol. 2020;18(10):571-586. doi: 10.1038/s41579-020-0385-0   Levin-Reisman I, Ronin I, Gefen O, Braniss I, Shoresh N, Balaban NQ. Antibiotic tolerance facilitates the evolution of resistance. Science. 2017;355(6327):826-830. doi: 10.1126/science.aaj2191   Stewart PS, Bjarnsholt T. Risk factors for chronic biofilm-related infection associated with implanted medical devices. Clin Microbiol Infect. 2020;26(8):1034-1038. doi: 10.1016/j.cmi.2020.02.027   Shao Y, Liu B, Di Z, et al. Engineering of Upconverted metal-organic frameworks for near-infrared light-triggered combinational photodynamic/chemo-/immunotherapy against hypoxic tumors. J Am Chem Soc. 2020;142(8):3939-3946. doi: 10.1021/jacs.9b12788   Galon J, Bruni D. Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Nat Rev Drug Discov. 2019;18(3):197-218. doi: 10.1038/s41573-018-0007-y   Frei A, Verderosa AD, Elliott AG, Zuegg J, Blaskovich MAT. Metals to combat antimicrobial resistance. Nat Rev Chem. 2023;7(3):202-224. doi: 10.1038/s41570-023-00463-4   Li S, Yue Y, Wang W, et al. Ultrasound-activated probiotics vesicles coating for titanium implant infections through bacterial cuproptosis-like death and immunoregulation. Adv Mater. 2024;36(44):e2405953. doi: 10.1002/adma.202405953   Su Z, Xu D, Hu X, et al. Biodegradable oxygen-evolving metalloantibiotics for spatiotemporal sono-metalloimmunotherapy against orthopaedic biofilm infections. Nat Commun. 2024;15(1):8058. doi: 10.1038/s41467-024-52489-x   Huang Y, Wan X, Su Q, et al. Ultrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections. Nat Commun. 2024;15(1):1643. doi: 10.1038/s41467-024-45619-y   Yang K, Halima A, Chan TA. Antigen presentation in cancer - mechanisms and clinical implications for immunotherapy. Nat Rev Clin Oncol. 2023;20(9):604-623. doi: 10.1038/s41571-023-00789-4   Zhang S, Zhang Y, Feng Y, et al. Biomineralized two-enzyme nanoparticles regulate tumor glycometabolism inducing tumor cell pyroptosis and robust antitumor immunotherapy. Adv Mater. 2022;34(50):e2206851. doi: 10.1002/adma.202206851   Geng J, Shi Y, Zhang J, et al. TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection. Nat Commun. 2021;12(1):3519. doi: 10.1038/s41467-021-23683-y   Zhang S, Yang H, Wang M, et al. Immunomodulatory biomaterials against bacterial infections: Progress, challenges, and future perspectives. Innovation (Camb). 2023;4(6):100503. doi: 10.1016/j.xinn.2023.100503   Roels HA, Bowler RM, Kim Y, et al. Manganese exposure and cognitive deficits: A growing concern for manganese neurotoxicity. Neurotoxicology. 2012;33(4):872-880. doi: 10.1016/j.neuro.2012.03.009