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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">BMT</journal-id><journal-title-group><journal-title>Biomaterials Translational</journal-title></journal-title-group><issn>TBA</issn><eissn>2096-112X</eissn><publisher><publisher-name>Biomaterials Translational</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.12336/biomatertransl.2022.03.004</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title>Engineered microorganism–based delivery systems for targeted cancer therapy: a narrative review</title><url>https://artdesignp.com/journal/BMT/3/3/10.12336/biomatertransl.2022.03.004</url><author>HuangXin,GuoHaoyu,WangLutong,ShaoZengwu</author><pub-date pub-type="publication-year"><year>2022</year></pub-date><volume>3</volume><issue>3</issue><history><date date-type="pub"><published-time>2022-09-28</published-time></date></history><abstract>Microorganisms with innate and artificial advantages have been regarded as intelligent drug delivery systems for cancer therapy with the help of engineering technology. Although numerous studies have confirmed the promising prospects of microorganisms in cancer, several problems such as immunogenicity and toxicity should be addressed before further clinical applications. This review aims to investigate the development of engineered microorganism&amp;ndash;based delivery systems for targeted cancer therapy. The main types of microorganisms such as bacteria, viruses, fungi, microalgae, and their components and characteristics are introduced in detail. Moreover, the engineering strategies and biomaterials design of microorganisms are further discussed. Most importantly, we discuss the innovative attempts and therapeutic effects of engineered microorganisms in cancer. Taken together, engineered microorganism&amp;ndash;based delivery systems hold tremendous promise for biomedical applications in targeted cancer therapy.</abstract><keywords>drug delivery systems, engineering strategies, microorganisms, targeted cancer therapy</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>1. Hosseinidoust, Z.; Mostaghaci, B.; Yasa, O.; Park, B. W.; Singh, A. V.; Sitti, M. Bioengineered and biohybrid bacteria-based systems for drug delivery. Adv Drug Deliv Rev. 2016, 106, 27-44. &amp;nbsp;2. Zhou, S.; Gravekamp, C.; Bermudes, D.; Liu, K. Tumour-targeting bacteria engineered to fight cancer. Nat Rev Cancer. 2018, 18, 727-743. &amp;nbsp;3. Dolgin, E. Fighting cancer with microbes. Nature. 2020, 577, S16-S18. &amp;nbsp;4. McAdams, H. H.; Srinivasan, B.; Arkin, A. P. The evolution of genetic regulatory systems in bacteria. 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