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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">BMT</journal-id><journal-title-group><journal-title>Biomaterials Translational</journal-title></journal-title-group><issn>TBA</issn><eissn>2096-112X</eissn><publisher><publisher-name>Biomaterials Translational</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.12336/biomatertransl.2024.04.008</article-id><article-categories><subj-group subj-group-type="heading"><subject>Commentary</subject></subj-group></article-categories><title>A novel strategy for treating acute liver failure: encapsulated proliferating human hepatocyte organoids</title><url>https://artdesignp.com/journal/BMT/5/4/10.12336/biomatertransl.2024.04.008</url><author>MengXiangying,LiuAihui,PhangthavongOulayvanh,SunYi</author><pub-date pub-type="publication-year"><year>2024</year></pub-date><volume>5</volume><issue>4</issue><history><date date-type="pub"><published-time>2024-12-28</published-time></date></history><abstract/><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>1. McSteen, B. W.; Ying, X. H.; Lucero, C.; Jesudian, A. B. Viral etiologies of acute liver failure. World J Virol. 2024, 13, 97973.2. Devarbhavi, H.; Asrani, S. K.; Arab, J. P.; Nartey, Y. A.; Pose, E.; Kamath, P. S. Global burden of liver disease: 2023 update. J Hepatol. 2023, 79, 516 - 537.3. Tadokoro, T.; Murata, S.; Kato, M.; Ueno, Y.; Tsuchida, T.; Okumura, A.; Kuse, Y.; Konno, T.; Uchida, Y.; Yamakawa, Y.; Zushi, M.; Yajima, M.; Kobayashi, T.; Hasegawa, S.; Kawakatsu - Hatada, Y.; Hayashi, Y.; Osakabe, S.; Maeda, T.; Kimura, K.; Mori, A.; Tanaka, M.; Kamishibahara, Y.; Matsuo, M.; Nie, Y. Z.; Okamoto, S.; Oba, T.; Tanimizu, N.; Taniguchi, H. Human iPSC - liver organoid transplantation reduces fibrosis through immunomodulation. Sci TranslMed. 2024, 16, eadg0338.4. Liu, Q.; Wang, S.; Fu, J.; Chen, Y.; Xu, J.; Wei, W.; Song, H.; Zhao, X.; Wang, H. Liver regeneration after injury: Mechanisms, cellular interactions and therapeutic innovations. Clin Transl Med. 2024, 14, e1812.5. Zhang, K.; Zhang, L.; Liu, W.; Ma, X.; Cen, J.; Sun, Z.; Wang, C.; Feng, S.; Zhang, Z.; Yue, L.; Sun, L.; Zhu, Z.; Chen, X.; Feng, A.; Wu, J.; Jiang, Z.; Li, P.; Cheng, X.; Gao, D.; Peng, L.; Hui, L. In vitro expansion of primary human hepatocytes with efficient liver repopulation capacity. Cell Stem Cell. 2018, 23, 806 - 819.e4.6. Fu, G. B.; Huang, W. J.; Zeng, M.; Zhou, X.; Wu, H. P.; Liu, C. C.; Wu, H.; Weng, J.; Zhang, H. D.; Cai, Y. C.; Ashton, C.; Ding, M.; Tang, D.; Zhang, B. H.; Gao, Y.; Yu, W. F.; Zhai, B.; He, Z. Y.; Wang, H. Y.; Yan, H. X. Expansion and differentiation of human hepatocyte - derived liver progenitor - like cells and their use for the study of hepatotropic pathogens. Cell Res. 2019, 29, 8 - 22.7. Yuan, X.; Wu, J.; Sun, Z.; Cen, J.; Shu, Y.; Wang, C.; Li, H.; Lin, D.; Zhang, K.; Wu, B.; Dhawan, A.; Zhang, L.; Hui, L. Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure. Cell Stem Cell. 2024, 31, 484 - 498.e5.8. Lee, K. Y.; Mooney, D. J. Alginate: properties and biomedical applications. Prog Polym Sci. 2012, 37, 106 - 126.9. Lopez - Mendez, T. B.; Santos - Vizcaino, E.; Pedraz, J. L.; Hernandez, R. M.; Orive, G. Cell microencapsulation technologies for sustained drug delivery: Clinical trials and companies. Drug Discov Today. 2021, 26, 852 - 861.10. Dhawan, A.; Chaijitraruch, N.; Fitzpatrick, E.; Bansal, S.; Filippi, C.; Lehec, S. C.; Heaton, N. D.; Kane, P.; Verma, A.; Hughes, R. D.; Mitry, R. R. Alginate microencapsulated human hepatocytes for the treatment of acute liver failure in children. J Hepatol. 2020, 72, 877 - 884.11. Fitzpatrick, E.; Filippi, C.; Jagadisan, B.; Shivapatham, D.; Anand, H.; Lyne, M.; Stroud, K. D.; Newton, R.; DeLord, M.; Douiri, A.; Dhawan, A. Intraperitoneal transplant of Hepatocytes co - Encapsulated with mesenchymal stromal cells in modified alginate microbeads for the treatment of acute liver failure in pediatric patients (HELP) - an open - label, single - arm Simon&amp;rsquo;s two stage phase 1 study protocol. PLoS One. 2023, 18, e0288185.12. Kang, A.; Park, J.; Ju, J.; Jeong, G. S.; Lee, S. H. Cell encapsulation via microtechnologies. Biomaterials. 2014, 35, 2651 - 2663.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
