<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">BMT</journal-id><journal-title-group><journal-title>Biomaterials Translational</journal-title></journal-title-group><issn>TBA</issn><eissn>2096-112X</eissn><publisher><publisher-name>Biomaterials Translational</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.12336/biomatertransl.2024.01.010</article-id><article-categories><subj-group subj-group-type="heading"><subject>Commentary</subject></subj-group></article-categories><title>HIF-1α: linking subchondral bone and cartilage as a therapeutic target in osteoarthritis</title><url>https://artdesignp.com/journal/BMT/5/1/10.12336/biomatertransl.2024.01.010</url><author>ZhangKaibo,FuWeili</author><pub-date pub-type="publication-year"><year>2024</year></pub-date><volume>5</volume><issue>1</issue><history><date date-type="pub"><published-time>2024-03-28</published-time></date></history><abstract/><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>1. Hu, W.; Chen, Y.; Dou, C.; Dong, S. Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis. Ann Rheum Dis. 2021, 80, 413-422.2. Hu, Y.; Chen, X.; Wang, S.; Jing, Y.; Su, J. Subchondral bone microenvironment in osteoarthritis and pain. Bone Res. 2021, 9, 20.3. Lampropoulou-Adamidou, K.; Dontas, I.; Stathopoulos, I. P.; Khaldi, L.; Lelovas, P.; Vlamis, J.; Triantafillopoulos, I. K.; Papaioannou, N. A. Chondroprotective effect of high-dose zoledronic acid: An experimental study in a rabbit model of osteoarthritis. J Orthop Res. 2014, 32, 1646-1651.4. Cai, G.; Aitken, D.; Laslett, L. L.; Pelletier, J. P.; Martel-Pelletier, J.; Hill, C.; March, L.; Wluka, A. E.; Wang, Y.; Antony, B.; Blizzard, L.; Winzenberg, T.; Cicuttini, F.; Jones, G. Effect of intravenous zoledronic acid on tibiofemoral cartilage volume among patients with knee osteoarthritis with bone marrow lesions: a randomized clinical trial. JAMA. 2020, 323, 1456-1466.5. Cui, Z.; Crane, J.; Xie, H.; Jin, X.; Zhen, G.; Li, C.; Xie, L.; Wang, L.; Bian, Q.; Qiu, T.; Wan, M.; Xie, M.; Ding, S.; Yu, B.; Cao, X. Halofuginone attenuates osteoarthritis by inhibition of TGF-&amp;beta; activity and H-type vessel formation in subchondral bone. Ann Rheum Dis. 2016, 75, 1714-1721.6. Hu, Y.; Wu, H.; Xu, T.; Wang, Y.; Qin, H.; Yao, Z.; Chen, P.; Xie, Y.; Ji, Z.; Yang, K.; Chai, Y.; Zhang, X.; Yu, B.; Cui, Z. Defactinib attenuates osteoarthritis by inhibiting positive feedback loop between H-type vessels and MSCs in subchondral bone. J Orthop Translat. 2020, 24, 12-22.7. Cui, Z.; Wu, H.; Xiao, Y.; Xu, T.; Jia, J.; Lin, H.; Lin, R.; Chen, K.; Lin, Y.; Li, K.; Wu, X.; Li, C.; Yu, B. Endothelial PDGF-BB/PDGFR-&amp;beta; signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation. Bone Res. 2022, 10, 58.8. Zhang, H.; Wang, L.; Cui, J.; Wang, S.; Han, Y.; Shao, H.; Wang, C.; Hu, Y.; Li, X.; Zhou, Q.; Guo, J.; Zhuang, X.; Sheng, S.; Zhang, T.; Zhou, D.; Chen, J.; Wang, F.; Gao, Q.; Jing, Y.; Chen, X.; Su, J. Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression. Sci Adv. 2023, 9, eabo7868.9. Li, X.; Wang, L.; Huang, B.; Gu, Y.; Luo, Y.; Zhi, X.; Hu, Y.; Zhang, H.; Gu, Z.; Cui, J.; Cao, L.; Guo, J.; Wang, Y.; Zhou, Q.; Jiang, H.; Fang, C.; Weng, W.; Chen, X.; Chen, X.; Su, J. Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss. Sci Adv. 2020, 6, eabb7135.10. Zeng, C. Y.; Wang, X. F.; Hua, F. Z. HIF-1&amp;alpha; in osteoarthritis: from pathogenesis to therapeutic implications. Front Pharmacol. 2022, 13, 927126.11. Hannah, S. S.; McFadden, S.; McNeilly, A.; McClean, C. &amp;ldquo;Take my bone away?&amp;rdquo; hypoxia and bone: a narrative review. J Cell Physiol. 2021, 236, 721-740.12. Al Hadi, H.; Smerdon, G. R.; Fox, S. W. Hyperbaric oxygen therapy suppresses osteoclast formation and bone resorption. J Orthop Res. 2013, 31, 1839-1844.13. Maruotti, N.; Corrado, A.; Cantatore, F. P. Osteoblast role in osteoarthritis pathogenesis. J Cell Physiol. 2017, 232, 2957-2963.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
