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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">BMT</journal-id><journal-title-group><journal-title>Biomaterials Translational</journal-title></journal-title-group><issn>TBA</issn><eissn>2096-112X</eissn><publisher><publisher-name>Biomaterials Translational</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.12336/biomatertransl.2021.02.002</article-id><article-categories><subj-group subj-group-type="heading"><subject>Viewpoint</subject></subj-group></article-categories><title>Orthopaedic tissue engineering and stem cells - an unfulfilled promise</title><url>https://artdesignp.com/journal/BMT/2/2/10.12336/biomatertransl.2021.02.002</url><author>T. TriffittJames</author><pub-date pub-type="publication-year"><year>2021</year></pub-date><volume>2</volume><issue>2</issue><history><date date-type="pub"><published-time>2021-06-28</published-time></date></history><abstract/><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>1. Friedenstein AJ, Chailakhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet 1987;20:263-272.2. Bianco P. Stem cells and bone: a historical perspective. Bone 2015;70:2-9.3. Cattaneo E, Corbellini G. Stem cells: taking a stand against pseudoscience. Nature 2014;510:333-335.4. Ambrosi TH, Longaker MT, Chan CKF. A revised perspective of skeletal stem cell biology. Front Cell Dev Biol 2019;7:189.5. Owen M, Friedenstein AJ. Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp 1988;136:42-60.6. Aubin JE, Triffitt JT. Chapter 4 - Mesenchymal stem cells and osteoblast differentiation. In: Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of bone biology, 2nd ed. San Diego: Academic Press; 2002. p. 59-81.7. Robey P. &amp;ldquo;Mesenchymal stem cells&amp;rdquo;: fact or fiction, and implications in their therapeutic use. F1000Res 2017;6:F1000 Faculty Rev-1524.8. Caplan AI. Medicinal signalling cells: they work, so use them. Nature 2019;566:39.9. Urist MR, Hay PH, Dubuc F, Buring K. Osteogenetic competence. Clin Orthop Relat Res 1969;64:194-220.10. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676.11. Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 1978;4:7-25.12. Lajtha L. Cellular kinetics of haemopoiesis. In: Hardisty RM, Weatherall DJ, editors. Blood and its disorders, 2nd ed. Oxford: Blackwell Scientific Publications; 1982. p. 57-74.13. Kurenkova AD, Medvedeva EV, Newton PT, Chagin AS. Niches for skeletal stem cells of mesenchymal origin. Front Cell Dev Biol 2020;8:592.14. Bingham GC, Lee F, Naba A, Barker TH. Spatial-omics: Novel approaches to probe cell heterogeneity and extracellular matrix biology. Matrix Biol 2020;91-92:152-166.15. Lundberg E, Borner GHH. Spatial proteomics: a powerful discovery tool for cell biology. Nat Rev Mol Cell Biol 2019;20:285-302.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
