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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">BMT</journal-id><journal-title-group><journal-title>Biomaterials Translational</journal-title></journal-title-group><issn>TBA</issn><eissn>2096-112X</eissn><publisher><publisher-name>Biomaterials Translational</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.12336/biomatertransl.2021.02.001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Editorial</subject></subj-group></article-categories><title>The cornerstone of translational research - selection of appropriate animal models</title><url>https://artdesignp.com/journal/BMT/2/2/10.12336/biomatertransl.2021.02.001</url><author>WangQian</author><pub-date pub-type="publication-year"><year>2021</year></pub-date><volume>2</volume><issue>2</issue><history><date date-type="pub"><published-time>2021-06-28</published-time></date></history><abstract/><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>1. Rollin BE. The experimental animal in biomedical research: a survey of scientific and ethical issues for investigators. Abingdon: Taylor &amp;amp; Francis; 1990.2. von Kortzfleisch VT, Karp NA, Palme R, Kaiser S, Sachser N, Richter SH. Improving reproducibility in animal research by splitting the study population into several &amp;lsquo;mini-experiments&amp;rsquo;. Sci Rep 2020;10:16579.3. Peng Y, Qing X, Shu H, Tian S, Yang W, Chen S, Lin H, Lv X, Zhao L, Chen X, Pu F, Huang D, Cao X, Shao Z. Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration. Biomater Transl 2021;2:91-142.4. Hong H, Wang X, Song X, El Fawal G, Wang K, Jiang D, Pei Y, Wang Z, Wang H. Transdermal delivery of interleukin-12 gene targeting dendritic cells enhances the anti-tumour effect of programmed cell death protein 1 monoclonal antibody. Biomater Transl 2021;2:151-164.5. Francis WR, Liu Z, Owens SE, Wang X, Xue H, Lord A, Kanamarlapudi V, Xia Z. Role of hypoxia inducible factor 1&amp;alpha; in cobalt nanoparticle induced cytotoxicity of human THP-1 macrophages. Biomater Transl 2021;2:143-150.6. Metavarayuth K, Villarreal E, Wang H, Wang Q. Surface topography and free energy regulate osteogenesis of stem cells: effects of shape-controlled gold nanoparticles. Biomater Transl 2021;2:165-173.7. Triffitt JT. Orthopaedic tissue engineering and stem cells &amp;ndash; an unfulfilled promise. Biomater Transl 2021;2:89-90.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
